Direction to Salk Pavilion is shown in campusmap0607 (UPITT campus) Salk Pavillion
Monday, August 8, 2016 – Morning Session
7:30 – 8:10 am Onsite Registration & Poster Set up (Salk Pavilion, Commons) (Light refreshments will be served.)
8:10 – 8:15 am Welcome by Dr. Xiang-Qun (Sean) Xie, CDAR Center Director
(Salk Room456) Opening Remarks by Dr. Arthur Levine, Senior Vice Chancellor for the Health Sciences, John and Gertrude Petersen Dean, School of Medicine
8:15 am – Noon Scientific Research Innovation (Invited Speakers) (Salk Room456)
8:15 – 8:55 am “Control the Deactivation of Cannabinergic Compounds “
by Dr. Alexandros Makriyannis, Professor,
George D. Behrakis Endowed Chair,
Director of the Center for Drug Discovery,
Northeastern University (35 + 5 min Q/A)
8:55 – 9:35 am “Statistical Thinking and Bayesian Thinking in Neuroscience”
by Dr. Robert E. Kass, Maurice Falk Professor of Statistics and Computational Neuroscience,
Interim Co-Director, Center for the Neural Basis of Cognition,
Carnegie Mellon University
(35 + 5 min Q/A)
9:35 – 10:15 am “Quantitative Systems Pharmacology (QSP) for Knowledge Integration and Hypothesis Generation in Pharmaceutical R&D”
by Dr. Tarek A. Leil, Group Director – Quantitative Clinical Pharmacology,
Clinical Pharmacology & Pharmacometrics – Exploratory Clinical and Translational Research (ECTR),
Bristol-Meyers Squibb
(35 + 5 min Q/A)
10:15 – 10:30 am Break (15 min)
(Chairperson: Dr. Ivet Bahar)
10:30 – 11:10 am “Mining LINCS Big Data to Knowledge”
by Dr. Avi Ma’ayan, Professor, Department of Pharmacology and Systems Therapeutics,
Director of the Mount Sinai Center for Bioinformatics,
Icahn Medical Institute
(35 + 5 min Q/A)
11:10 – Noon Keynote Presentation – “Translational Data Science at Merck”
by Dr. Christopher Waller,
Executive Director of MRLIT Modeling Platforms and CORE at Merck
(45 + 5 min Q/A)
Noon – 1:00 pm Lunch & Poster Presentations (Salk Pavilion, Commons)
Monday, August 8, 2016 – Afternoon Session (Salk Room 456)
1:00 – 1:15 pm “UPMC’s Big Data Initiative”
by Dr. Steven D. Shapiro, Executive Vice President,
UPMC Chief Medical and Scientific Officer
President, Health Services Division (10 + 5 min Q/A)
1:15 – 1:45 pm Special Talk – “NIDA’s Basic Chemistry Research and Translational Areas of Interest”
by Dr. Rao Rapaka,
Branch Chief of NIH NIDA
(25 + 5 min Q/A)
1:45 – 3:30 pm CDAR Core Research Reports (Salk Room 456)
1:45 – 2:20 pm “Disease-Specific Chemogenomics Knowledgebases and TargetHunter© for Drug Abuse and Neurodisorder Research and System Pharmacology”
by Dr. Xiang-Qun (Sean) Xie (Core A), Professor and Associate Dean,
Department of Pharmaceutical Sciences & Drug Discovery Institute,
Director of CDAR Center
(25 + 10 min Q/A)
2:20 – 2:55 pm “Insights into the Molecular Mechanisms of Function of Neurotransmitter Transporters and Ionotropic Glutamate Receptors”
by Dr. Ivet Bahar (Core B), Distinguished Professor & JK Vries Chair
Department of Computational & Systems Biology,
Associate Director of University of Pittsburgh Drug Discovery Institute
(25 + 10 min Q/A)
2:55 – 3:30 pm “Toward Personalized Pan-Omic Association Analysis under Complex Structures”
by Dr.Eric Xing (Core C), Professor,
Machine Learning Department & Language Technology Institute & Computer Science department,
Director of Center for Machine Learning and Health, Carnegie Mellon University
(25 + 10 min Q/A)
3:30 – 4:00 pm Coffee break & Poster session, Group photo (Salk Pavilion, Commons)
Poster Evaluation
4:00 – 6:00 pm Funded Research Projects (FRP) & Pilot Project Reports (Salk Room 456)
4:00 – 4:20 pm “Targeting Cannabinoid Receptor-2 to Reduce Renal Fibrosis”, by Dr. Youhua Liu, Professor, Department of Pathology, University of Pittsburgh (15 + 5 min Q/A)
4:20 – 4:40 pm “b2-Adrenergic Receptor Responses and Asthma: Modulation through Protein-Lipid Interactions” by Dr. Sally E. Wenzel, Professor of Medicine & Director of University of Pittsburgh Asthma Institute @ UPMC/UPSOM (15 + 5 min Q/A)
4:40 – 5:00 pm “New strategies to manage opioid addiction and pain”, by Dr. Manojkumar Puthenveedu, Associate Professor, Biological Sciences and The Center for the Neural Basis of Cognition, Carnegie Mellon University (15 + 5 min Q/A)
5:00 – 5:10 pm “AB vs. ADB: One Methyl Makes a Large Difference”, by Joshua Yohannan, MS, Laboratory Manager of The Allegheny County Medical Examiner’s Office (8 + 2 min Q/A)
5:10 – 5:20 pm “Defining the Higher Order Structures of GPCR Signaling Complexes for Drug Discovery”, by Dr. Kevin Xiao, Associate Professor, Department of Pharmacology and Chemical Biology, University of Pittsburgh (8 + 2 min Q/A)
5:20 – 5:30 pm “Do the behavioral effects of dopamine transporter (DAT) inhibitors correlate with DAT conformation preference?” by Dr. Christopher K. Surratt, Professor of Pharmacology, Mylan School of Pharmacy, Duquesne University (8 + 2 min Q/A)
5:30 – 6:00 pm Training, Dissemination and Administration
****Graduate Student Poster Awards****
6:00 pm Meeting Adjourned until Tuesday
6:00 – 8:30 pm Dinner (External Advisory Board Members, CDAR Leaders, Pitt/CMU Admins)
(Salk Pavilion, CVS Conference Room)
Tuesday, August 9, 2016
7:30 – 8:00 am Breakfast & Poster
8:00 – 10:00 am Poster Session (Salk Pavilion, Commons)
9:00 – 12:00 noon Business Meetings (Salk Pavilion, CVS Conference Room)
9:00 – 10:00 am Meeting of EAB members only
10:00 – 11:00 am Meeting of EAB members with the CDAR Leadership
11:00 – Noon EAB members only, wrap up/write the summary report
12:00 – 1:30 pm Concluding Remarks & Boxed Lunch
Training Workshop for Registered Attendees (BST3, Room 3073**)
1:30 – 3:00 pm Core A Training (30 minute lecture and 1 hour demo & practice)
Training topics:
(1) Chemogenomics Database for Drug Abuse & Neuro-disorders: Genes, protein targets, pathways involved in a disease and small molecules that can directly interact with these key proteins with the potential to modulate the disease.
(2) TargetHunerMap: To predict the potential protein target(s) of a small molecule drug or a chemical compound through structure similarity or molecular docking.
(3) BBB prediction: To predict the blood-brain barrier (BBB) permeability of a small molecule based on its chemical features.
3:00 – 4:30 pm Core B Training (30 minute lecture and 1 hour demo & practice)
Training topics:
(1) ANM (Anisotropic network model): an elastic network based tool for analysis of dynamics of proteins and nucleic acids.
(2) ProDy: a free and open-source Python package for protein structural dynamics and sequence analysis.
(3)Druggability simulations: the use of DRUGUI, a VMD plugin, for performing MD simulations for druggability assessment, using probe molecules.
4:30 – 6:00 pm Core C Training (30 minute lecture and 1 hour demo & practice)
Training topic:
GenAMap: GenAMap software is a powerful platform for detection and easy visualization of structured association of genomic data and physical traits.
**Please note, BST3 is a high security building. We will need to go together as a group so that no one is inadvertently left out.